After Louie explores the contradictions of modern gay life and history through Sam, a man desperate to understand how he and his community got to where they are today. As an AIDS activist and member of ACT UP in the 1980s and 90s, Sam witnessed the deaths of too many friends and lovers. Battlewounded and struggling with survivor's guilt, Sam now resents the complacency of his former comrades and derides what he sees as the younger generation's indifference to the politics of sex, and of death....

Monty Wildhorn, an alcoholic novelist of Westerns, has lost his drive. His nephew pushes him to summer in quiet Belle Isle. He begrudgingly befriends a newly single mom and her 3 girls who help him find the inspiration to write again.